The PC Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PC, PCB, PCLP1, Pcx, Podocalyxin, podocalyxin like, PODXL, PROC, PROC1, Protein C, pyruvate carboxylase, and THPH3. This antibody recognizes Human, Mouse, and Rat antigen. The PC Polyclonal Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene